Neutrophil Extracellular Traps in Systemic Lupus Erythematosus Stimulate IgG2 Production From B Lymphocytes

Neutrophil Extracellular Traps in Systemic Lupus Erythematosus Stimulate IgG2 Production From B Lymphocytes

Circulating autoantibodies of IgG2 isotype predominate in Systemic Lupus Erythematosus (SLE) and concur to the development of the renal lesions characteristic of Lupus Nephritis (LN). Anti-dsDNA and anti-histones IgG2, together with anti-podocyte proteins (i.e., α-enolase) are the major autoantibodi...

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Bibliographic Details
Main Authors: Roberta Bertelli, Francesca Schena, Francesca Antonini, Daniele Reverberi, Sara Signa, Nicoletta Pedemonte, Alessandro Consolaro, Marco Gattorno, Simone Negrini, Francesca Pupo, Stefano Volpi, Gian Marco Ghiggeri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Medicine
Subjects:
lupus nephritis
autoimmunity
NETosis
T-bet
IgG2
naïve B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.635436/full

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https://www.frontiersin.org/articles/10.3389/fmed.2021.635436/full

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