The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells
Summary: IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3+ Treg cells, however, express uniquely low amounts of the IL-7-proprietary IL-7Rα so that they are impaired in IL-7 signaling. Because Treg cells depend on IL-2, the loss...
Автори: | , , , , , , , , |
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Формат: | Стаття |
Мова: | English |
Опубліковано: |
Elsevier
2020-08-01
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Серія: | iScience |
Предмети: | |
Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S2589004220306118 |