The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells

The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells

Summary: IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3+ Treg cells, however, express uniquely low amounts of the IL-7-proprietary IL-7Rα so that they are impaired in IL-7 signaling. Because Treg cells depend on IL-2, the loss...

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Bibliographic Details
Main Authors: Adam T. Waickman, Hilary R. Keller, Tae-Hyoun Kim, Megan A. Luckey, Xuguang Tai, Changwan Hong, Carmen Molina-París, Scott T.R. Walsh, Jung-Hyun Park
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Molecular Biology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306118

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