Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice

Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice

p21-Activated kinase 4 (PAK4), one of the serine/threonine kinases activated by Rho-family GTPases, has been widely studied as an oncogenic protein that is overexpressed in many types of cancers. In our recent study, PAK4 upregulation was observed in mice exhibiting hepatic ischaemia-reperfusion (I/...

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Bibliographic Details
Main Authors: Yuancheng Mao, Eun Lee, Xiaohui Yang, Eun Ju Bae, Raok Jeon, Byung-Hyun Park
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
PAK4
pyrazolo[3,4-d]pyrimidine
liver
ischaemia-reperfusion
hypoxia-reoxygenation
Nrf2
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2106478

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2022.2106478

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