NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis.

NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis.

Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells cannot control the parasites, they significantly contribute to pathologic responses. In a murine model of cutaneous...

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Bibliographic Details
Main Authors: Laís A Sacramento, Camila Farias Amorim, Taís M Campos, Maíra Saldanha, Sérgio Arruda, Lucas P Carvalho, Daniel P Beiting, Edgar M Carvalho, Fernanda O Novais, Phillip Scott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0011552

Internet

https://doi.org/10.1371/journal.pntd.0011552

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