Neddylation inhibition activates the protective autophagy through NF-κB-catalase-ATF3 Axis in human esophageal cancer cells

Neddylation inhibition activates the protective autophagy through NF-κB-catalase-ATF3 Axis in human esophageal cancer cells

Abstract Background Protein neddylation plays a tumor-promoting role in esophageal cancer. Our previous study demonstrated that neddylation inhibition induced the accumulation of ATF4 to promote apoptosis in esophageal cancer cells. However, it is completely unknown whether neddylation inhibition co...

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Bibliographic Details
Main Authors: Yupei Liang, Yanyu Jiang, Xing Jin, Ping Chen, Yongqing Heng, Lili Cai, Wenjuan Zhang, Lihui Li, Lijun Jia
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cell Communication and Signaling
Subjects:
Neddylation
MLN4924
NF-κB/catalase/ATF3
Autophagy
Apoptosis
Esophageal Cancer
Online Access:http://link.springer.com/article/10.1186/s12964-020-00576-z

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http://link.springer.com/article/10.1186/s12964-020-00576-z

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