Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway

Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway

There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the production of testosterone. Increasing evidence shows that melatonin benefits the reproductive process. This study mainly explores the protective effect and possible molecular mechanism of melatonin regarding ci...

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Bibliographic Details
Main Authors: Junqiang Zhang, Yuan Fang, Dongdong Tang, Xingyu Xu, Xiaoqian Zhu, Shusheng Wu, Hui Yu, Huiru Cheng, Ting Luo, Qunshan Shen, Yang Gao, Cong Ma, Yajing Liu, Zhaolian Wei, Xiaoyu Chen, Fangbiao Tao, Xiaojin He, Yunxia Cao
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
melatonin
oxidative stress
melatonin receptor
SIRT1
Nrf2
Leydig cell
Online Access:https://www.mdpi.com/2073-4409/11/10/1690

Internet

https://www.mdpi.com/2073-4409/11/10/1690

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