Utility of Serial Donor-derived Cell-free DNA Measurements for Detecting Allograft Rejection in a Kidney Transplant Recipient After PD-1 Checkpoint Inhibitor Administration

Utility of Serial Donor-derived Cell-free DNA Measurements for Detecting Allograft Rejection in a Kidney Transplant Recipient After PD-1 Checkpoint Inhibitor Administration

Background. Donor-derived cell-free DNA (dd-cfDNA) is a useful biomarker of rejection that originates from allograft cells undergoing injury. Plasma levels <1% in kidney transplant recipients have a high negative predictive value for active allograft rejection. The utility of this biomarker in ki...

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Bibliographic Details
Main Authors: Laila Lakhani, MD, Sami Alasfar, MD, Anshul Bhalla, MD, Amtul Aala, MD, Avi Rosenberg, MD, Darin Ostrander, PhD, Megan D. Schollenberger, CRNP, Daniel C. Brennan, MD, Evan J. Lipson, MD
Format: Article
Language:English
Published: Wolters Kluwer 2021-02-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001113

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http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001113

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