Thyroxine (T4) Transfer from Blood to Cerebrospinal Fluid in Sheep Isolated Perfused Choroid Plexus: Role of Multidrug Resistance-Associated Proteins and Organic Anion Transporting Polypeptides

Thyroxine (T4) Transfer from Blood to Cerebrospinal Fluid in Sheep Isolated Perfused Choroid Plexus: Role of Multidrug Resistance-Associated Proteins and Organic Anion Transporting Polypeptides

Thyroxine (T4) enters the brain either directly across the blood–brain barrier (BBB) or indirectly via the choroid plexus (CP), which forms the blood–cerebrospinal fluid barrier (B-CSF-B). In this study, using isolated perfused CP of the sheep by single-circulation paired tracer and steady-state tec...

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Bibliographic Details
Main Authors: Kazem Zibara, Nabil El Zein, Mirna Sabra, Mohammad Hneino, Hayat Harati, Wael Mohamed, Firas H. Kobeissy, Nouhad Kassem
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Neurology
Subjects:
transport
thyroid hormone
blood–cerebrospinal fluid barrier
blood–brain barrier
efflux
uptake
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00214/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2017.00214/full

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