Deacylcynaropicrin Inhibits RANKL-Induced Osteoclastogenesis by Inhibiting NF-κB and MAPK and Promoting M2 Polarization of Macrophages

Deacylcynaropicrin Inhibits RANKL-Induced Osteoclastogenesis by Inhibiting NF-κB and MAPK and Promoting M2 Polarization of Macrophages

Inflammation can promote the maturity of osteoclasts and bone resorption in many bone disease such as osteoporosis and arthritis. Here, we aimed to investigate the inhibitory effects of deacylcynaropicrin (DAC) on osteoclastogenesis and bone resorption induced by RANKL. Bone-marrow-derived macrophag...

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Bibliographic Details
Main Authors: Zhikun Li, Xiaodong Zhu, Ruijun Xu, Yi Wang, Ruixi Hu, Wei Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
deacylcynaropicrin
osteoclastogenesis
MAPK
NF-κB
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00599/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00599/full

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