Recent Advances in the Digestive, Metabolic and Therapeutic Effects of Farnesoid X Receptor and Fibroblast Growth Factor 19: From Cholesterol to Bile Acid Signaling

Recent Advances in the Digestive, Metabolic and Therapeutic Effects of Farnesoid X Receptor and Fibroblast Growth Factor 19: From Cholesterol to Bile Acid Signaling

Bile acids (BA) are amphiphilic molecules synthesized in the liver (primary BA) starting from cholesterol. In the small intestine, BA act as strong detergents for emulsification, solubilization and absorption of dietary fat, cholesterol, and lipid-soluble vitamins. Primary BA escaping the active ile...

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Bibliographic Details
Main Authors: Agostino Di Ciaula, Leonilde Bonfrate, Jacek Baj, Mohamad Khalil, Gabriella Garruti, Frans Stellaard, Helen H. Wang, David Q.-H. Wang, Piero Portincasa
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Nutrients
Subjects:
bile acids
nonalcoholic fatty liver disease
FGF15/19
FXR
agonist
nuclear receptors
Online Access:https://www.mdpi.com/2072-6643/14/23/4950

Internet

https://www.mdpi.com/2072-6643/14/23/4950

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