Cryo-EM structures of intact V-ATPase from bovine brain

The vacuolar-type H+ -ATPases (V-ATPase) hydrolyze ATP to pump protons across the plasma or intracellular membrane. Here authors report two cryo-EM structures of the intact V-ATPase from bovine brain with all the subunits including the subunit H, which is essential for ATPase activity.

Bibliographic Details
Main Authors: Rong Wang, Tao Long, Abdirahman Hassan, Jin Wang, Yingyuan Sun, Xiao-Song Xie, Xiaochun Li
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17762-9