Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with <sup>89</sup>Zr Radioisotope in Mice and Rats

Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with <sup>89</sup>Zr Radioisotope in Mice and Rats

For the successful clinical advancement of exosome therapeutics, the biodistribution and pharmacokinetic profile of exogenous exosomes in various animal models must be determined. Compared with fluorescence or bioluminescence imaging, radionuclide imaging confers multiple advantages for the in vivo...

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Bibliographic Details
Main Authors: Hojun Choi, Myung-Yoon Kim, Dae-Hwan Kim, Hanoul Yun, Byung-Koo Oh, Su-Bin Kim, In-Ho Song, Hyun-Soo Park, Sang-Eun Kim, Cheolhyoung Park, Chulhee Choi
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
exosome
biodistribution
pharmacokinetics
zirconium
positron emission tomography/computed tomography
Online Access:https://www.mdpi.com/1999-4923/14/6/1118

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https://www.mdpi.com/1999-4923/14/6/1118

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