Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World <i>Leishmania</i> Species

Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World <i>Leishmania</i> Species

The bifunctional enzyme Dihydrofolate reductase-thymidylate synthase (DHFR-TS) plays a crucial role in the survival of the <i>Leishmania</i> parasite, as folates are essential cofactors for purine and pyrimidine nucleotide biosynthesis. However, DHFR inhibitors are largely ineffective in...

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Bibliographic Details
Main Authors: Chonny Herrera-Acevedo, Renata Priscila Barros de Menezes, Natália Ferreira de Sousa, Luciana Scotti, Marcus Tullius Scotti, Ericsson Coy-Barrera
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Antibiotics
Subjects:
kauranes
<i>Leishmania</i>
Asteraceae
machine learning
DHFR-TS
diterpenes
Online Access:https://www.mdpi.com/2079-6382/12/4/663

Internet

https://www.mdpi.com/2079-6382/12/4/663

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