How Localized Z-Disc Damage Affects Force Generation and Gene Expression in Cardiomyocytes

How Localized Z-Disc Damage Affects Force Generation and Gene Expression in Cardiomyocytes

The proper function of cardiomyocytes (CMs) is highly related to the Z-disc, which has a pivotal role in orchestrating the sarcomeric cytoskeletal function. To better understand Z-disc related cardiomyopathies, novel models of Z-disc damage have to be developed. Human pluripotent stem cell (hPSC)-de...

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Bibliographic Details
Main Authors: Dominik Müller, Sören Donath, Emanuel Georg Brückner, Santoshi Biswanath Devadas, Fiene Daniel, Lara Gentemann, Robert Zweigerdt, Alexander Heisterkamp, Stefan Michael Klaus Kalies
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Bioengineering
Subjects:
femtosecond laser manipulation
cardiomyocyte
Z-disc
traction forces
Online Access:https://www.mdpi.com/2306-5354/8/12/213

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https://www.mdpi.com/2306-5354/8/12/213

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