Doxycycline reduces liver and kidney injuries in a rat hemorrhagic shock model

Doxycycline reduces liver and kidney injuries in a rat hemorrhagic shock model

Abstract Background Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney, and liver tissue from damage in a rat model of HS. Immediately before...

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Bibliographic Details
Main Authors: Regina Sordi, Luana Bojko, Filipe R. M. B. Oliveira, Thiele Osvaldt Rosales, Camila Fernandes Souza, Lucas Wenceslau Moreno, Gustavo Ferreira Alves, José Carlos Rebuglio Vellosa, Daniel Fernandes, Jose Rosa Gomes
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:Intensive Care Medicine Experimental
Subjects:
Hypovolemic shock
Hemorrhage
Nitric oxide
Creatinine
Drug repurposing
Organ failure
Online Access:https://doi.org/10.1186/s40635-023-00586-4

Internet

https://doi.org/10.1186/s40635-023-00586-4

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