A PRMT5 inhibitor protects against noise-induced hearing loss by alleviating ROS accumulation

A PRMT5 inhibitor protects against noise-induced hearing loss by alleviating ROS accumulation

The aim of this study was to investigate the effect of LLY-283, a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), on a noise-induced hearing loss (NIHL) mouse model and to identify a potential target for a therapeutic intervention against NIHL. Eight-week-old male C57BL/6 mice w...

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Bibliographic Details
Main Authors: Chang Liu, Dongmei Tang, Zhiwei Zheng, Xiaoling Lu, Wen Li, Liping Zhao, Yingzi He, Huawei Li
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PRMT5
NIHL
Hair cell
Spiral ganglion neurons
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322008326

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http://www.sciencedirect.com/science/article/pii/S0147651322008326

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