GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition

GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition

Previous studies show that glycogen synthase kinase 3β (GSK3B) plays an important role in tumorigenesis. However, its role in cervical cancer is unclear. The present study silenced GSK3B with siRNAs and/or chemical inhibitors to determine its role in HeLa cervical cancer cell proliferation and migra...

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Bibliographic Details
Main Authors: Yanhong Zheng, Yang Yang, Weiyan Zhu, Ruhao Liu, Aodong Liu, Runfeng Zhang, Weixing Lei, Shifeng Huang, Yongzhu Liu, Qinglan Hu
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2024-08-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Cell proliferation and migration
Cervical cancer
Epithelial-to-mesenchymal transition
Glycogen synthase kinase 3β
Phosphatidylinositol 3-carboxykinase/protein kinase B signaling pathway
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2024000100668&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2024000100668&lng=en&tlng=en

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