Optimized POCl3-assisted synthesis of 2-amino-1,3,4-thiadiazole/1,3,4-oxadiazole derivatives as anti-influenza agents

Optimized POCl3-assisted synthesis of 2-amino-1,3,4-thiadiazole/1,3,4-oxadiazole derivatives as anti-influenza agents

Although recent decades have witnessed the synthesis of 1,3,4-thiadiazoles via phosphorus POCl3-promoted cyclization reaction, simultaneous access to 2-amino-1,3,4-thiadiazole and 2-amino-1,3,4-oxadiazole analogs remains unexpected and elusive. Herein, a detailed regiocontrolled synthesis of 2-amino...

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Bibliographic Details
Main Authors: Jianghong Dong, Qinglan Pei, Panpan Wang, Qinge Ma, Wenhui Hu
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Arabian Journal of Chemistry
Subjects:
2-amino-1,3,4-thiadiazole
Dehydrative cyclization
Phosphorus oxychloride
Regioselectivity
Anti-influenza activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222000284

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http://www.sciencedirect.com/science/article/pii/S1878535222000284

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