Sildenafil decreases rat tracheal hyperresponsiveness to carbachol and changes canonical transient receptor potential gene expression after antigen challenge

Sildenafil decreases rat tracheal hyperresponsiveness to carbachol and changes canonical transient receptor potential gene expression after antigen challenge

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Inhibition of type-5 phosphodiesterase by sildenafil decreases capacitative Ca2+ entry mediated by transient receptor potential proteins (TRPs) in the pulmonary artery. These families of channels, especially the canonical TRP (TRPC) subfamily, may be involved in the development of bronchial hyperres...

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Bibliographic Details
Main Authors: C.T. Sousa, T.S. Brito, F.J.B. Lima, R.J.B. Siqueira, P.J.C. Magalhães, A.A.M. Lima, A.A. Santos, A. Havt
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-06-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Asthma
Ovalbumin
Capacitative Ca2+ entry
Transient receptor potential proteins
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000600010&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000600010&lng=en&tlng=en

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