Replication-incompetent influenza A viruses armed with IFN-γ effectively mediate immune modulation and tumor destruction in mice harboring lung cancer

Replication-incompetent influenza A viruses armed with IFN-γ effectively mediate immune modulation and tumor destruction in mice harboring lung cancer

Low pathogenic influenza A viruses (IAVs) have shown promising oncolytic potential in lung cancer–bearing mice. However, as replication-competent pathogens, they may cause side effects in immunocompromised cancer patients. To circumvent this problem, we genetically engineered nonreplicating IAVs lac...

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Bibliographic Details
Main Authors: Ramona Meissner, Viktor Wixler, Franziska Paulina Wulfert, Jasmin Carina Jacob, Benjamin G. Hale, Thomas Robeck, Dörthe Masemann, Yvonne Boergeling, Stephan Ludwig
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
replication-incompetent influenza A viruses
hemagglutinin gene-deficiency
single-cycle viruses
interferon gamma
oncolytic viruses
non-small cell lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000906

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http://www.sciencedirect.com/science/article/pii/S2372770523000906

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