Patient-derived melanoma organoid models facilitate the assessment of immunotherapiesResearch in context

Patient-derived melanoma organoid models facilitate the assessment of immunotherapiesResearch in context

Summary: Background: Only a minority of melanoma patients experience durable responses to immunotherapies due to inter- and intra-tumoral heterogeneity in melanoma. As a result, there is a pressing need for suitable preclinical models to investigate resistance mechanisms and enhance treatment effic...

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Main Authors: Lingling Ou, Shujing Liu, Huaishan Wang, Yeye Guo, Lei Guan, Longbin Shen, Ruhui Luo, David E. Elder, Alexander C. Huang, Giorgos Karakousis, John Miura, Tara Mitchell, Lynn Schuchter, Ravi Amaravadi, Ahron Flowers, Haiwei Mou, Fan Yi, Wei Guo, Jina Ko, Qing Chen, Bin Tian, Meenhard Herlyn, Xiaowei Xu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:EBioMedicine
Subjects:
Melanoma patient-derived organoids (MPDOs)
Tumor microenvironment (TME)
Tumor infiltrating lymphocytes (TILs)
Anti-PD-1 antibodies
Small molecule inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423001792

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http://www.sciencedirect.com/science/article/pii/S2352396423001792

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