The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS

The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS

The modification of lipopolysaccharide (LPS) in Escherichia coli and Salmonella spp. is primarily controlled by the two-component system PmrAB. LPS modification allows bacteria to avoid killing by positively charged antibiotics like polymyxin B (PMB). We previously demonstrated that in uropathogenic...

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Bibliographic Details
Main Authors: Melanie N. Hurst, Connor J. Beebout, Alexis Hollingsworth, Kirsten R. Guckes, Alexandria Purcell, Tomas A. Bermudez, Diamond Williams, Seth A. Reasoner, M. Stephen Trent, Maria Hadjifrangiskou
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mSphere
Subjects:
antibiotics
tolerance
UPEC
amino acid metabolism
QseB
Online Access:https://journals.asm.org/doi/10.1128/msphere.00059-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00059-23

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