The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS
The modification of lipopolysaccharide (LPS) in Escherichia coli and Salmonella spp. is primarily controlled by the two-component system PmrAB. LPS modification allows bacteria to avoid killing by positively charged antibiotics like polymyxin B (PMB). We previously demonstrated that in uropathogenic...
Main Authors: | Melanie N. Hurst, Connor J. Beebout, Alexis Hollingsworth, Kirsten R. Guckes, Alexandria Purcell, Tomas A. Bermudez, Diamond Williams, Seth A. Reasoner, M. Stephen Trent, Maria Hadjifrangiskou |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2023-10-01
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Series: | mSphere |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/msphere.00059-23 |
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