Induction and Prevention of Gastric Cancer with Combined <i>Helicobacter Pylori</i> and Capsaicin Administration and DFMO Treatment, Respectively
Gastric cancer risk evolves over time due to environmental, dietary, and lifestyle changes, including <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and consumption of hot peppers (i.e., capsaicin). <i>H. pylori</i> infection promotes gastric mucosal inju...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/4/816 |
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| author | Faisal Aziz Mingxia Xin Yunfeng Gao Abhijit Chakroborty Imran Khan Josh Monts Kjersten Monson Ann M. Bode Zigang Dong |
| author_facet | Faisal Aziz Mingxia Xin Yunfeng Gao Abhijit Chakroborty Imran Khan Josh Monts Kjersten Monson Ann M. Bode Zigang Dong |
| author_sort | Faisal Aziz |
| collection | DOAJ |
| description | Gastric cancer risk evolves over time due to environmental, dietary, and lifestyle changes, including <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and consumption of hot peppers (i.e., capsaicin). <i>H. pylori</i> infection promotes gastric mucosal injury in the early phase of capsaicin exposure. This relationship suggests a need to investigate the mechanism of how both <i>H. pylori</i> infection and capsaicin contribute to gastric inflammation and lead to gastric cancer. C57-Balb/c mice were infected with the <i>H. pylori</i> (SS1) strain and then fed capsaicin (0.05% or 0.2 g/kg/day) or not. Consequently, tumor size and phenotype were analyzed to determine the molecular mechanism driving the shift from gastritis to stomach cancer. Moreover, we used 2-difluoromethylornithine (DFMO) in mice to prevent gastric tumorigenesis by reducing inflammation and promoting recovery of disease-free stasis. This study provides evidence showing that a combination of <i>H. pylori</i> infection and capsaicin consumption leads to gastric carcinogenesis mediated through interleukin-6 (IL-6) stimulation with an incidence rate of 50%. The anti-inflammatory role of DFMO highlights the injurious effect of inflammation in gastric cancer development and the need to reduce gastric inflammation for cancer prevention by inhibiting IL-6. Accordingly, preventive measures such as reduced capsaicin consumption, <i>H. pylori</i> clearance, and DFMO treatment may lessen gastric cancer incidence. |
| first_indexed | 2024-03-11T10:11:18Z |
| format | Article |
| id | doaj.art-e04bf5f41b514b66a4f49c9b43cacc33 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T10:11:18Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e04bf5f41b514b66a4f49c9b43cacc332023-11-16T14:33:29ZengMDPI AGCancers2072-66942020-03-0112481610.3390/cancers12040816Induction and Prevention of Gastric Cancer with Combined <i>Helicobacter Pylori</i> and Capsaicin Administration and DFMO Treatment, RespectivelyFaisal Aziz0Mingxia Xin1Yunfeng Gao2Abhijit Chakroborty3Imran Khan4Josh Monts5Kjersten Monson6Ann M. Bode7Zigang Dong8The Hormel Institute, University of Minnesota, Austin, MN 55912, USAChina–US (Henan) Cancer Institute, Zhengzhou, Henan 450003, ChinaChina–US (Henan) Cancer Institute, Zhengzhou, Henan 450003, ChinaThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAThe Hormel Institute, University of Minnesota, Austin, MN 55912, USAGastric cancer risk evolves over time due to environmental, dietary, and lifestyle changes, including <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and consumption of hot peppers (i.e., capsaicin). <i>H. pylori</i> infection promotes gastric mucosal injury in the early phase of capsaicin exposure. This relationship suggests a need to investigate the mechanism of how both <i>H. pylori</i> infection and capsaicin contribute to gastric inflammation and lead to gastric cancer. C57-Balb/c mice were infected with the <i>H. pylori</i> (SS1) strain and then fed capsaicin (0.05% or 0.2 g/kg/day) or not. Consequently, tumor size and phenotype were analyzed to determine the molecular mechanism driving the shift from gastritis to stomach cancer. Moreover, we used 2-difluoromethylornithine (DFMO) in mice to prevent gastric tumorigenesis by reducing inflammation and promoting recovery of disease-free stasis. This study provides evidence showing that a combination of <i>H. pylori</i> infection and capsaicin consumption leads to gastric carcinogenesis mediated through interleukin-6 (IL-6) stimulation with an incidence rate of 50%. The anti-inflammatory role of DFMO highlights the injurious effect of inflammation in gastric cancer development and the need to reduce gastric inflammation for cancer prevention by inhibiting IL-6. Accordingly, preventive measures such as reduced capsaicin consumption, <i>H. pylori</i> clearance, and DFMO treatment may lessen gastric cancer incidence.https://www.mdpi.com/2072-6694/12/4/816capsaicinDFMOgastric inflammationgastric cancer<i>Helicobacter. pylori</i>IL-6 |
| spellingShingle | Faisal Aziz Mingxia Xin Yunfeng Gao Abhijit Chakroborty Imran Khan Josh Monts Kjersten Monson Ann M. Bode Zigang Dong Induction and Prevention of Gastric Cancer with Combined <i>Helicobacter Pylori</i> and Capsaicin Administration and DFMO Treatment, Respectively Cancers capsaicin DFMO gastric inflammation gastric cancer <i>Helicobacter. pylori</i> IL-6 |
| title | Induction and Prevention of Gastric Cancer with Combined <i>Helicobacter Pylori</i> and Capsaicin Administration and DFMO Treatment, Respectively |
| title_full | Induction and Prevention of Gastric Cancer with Combined <i>Helicobacter Pylori</i> and Capsaicin Administration and DFMO Treatment, Respectively |
| title_fullStr | Induction and Prevention of Gastric Cancer with Combined <i>Helicobacter Pylori</i> and Capsaicin Administration and DFMO Treatment, Respectively |
| title_full_unstemmed | Induction and Prevention of Gastric Cancer with Combined <i>Helicobacter Pylori</i> and Capsaicin Administration and DFMO Treatment, Respectively |
| title_short | Induction and Prevention of Gastric Cancer with Combined <i>Helicobacter Pylori</i> and Capsaicin Administration and DFMO Treatment, Respectively |
| title_sort | induction and prevention of gastric cancer with combined i helicobacter pylori i and capsaicin administration and dfmo treatment respectively |
| topic | capsaicin DFMO gastric inflammation gastric cancer <i>Helicobacter. pylori</i> IL-6 |
| url | https://www.mdpi.com/2072-6694/12/4/816 |
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