Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression.

Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression.

Intermittent hypoxia (IH) is a major clinical feature of obstructive sleep apnea (OSA). The mechanisms that become dysregulated after periods of exposure to IH are unclear, particularly in the early stages of disease. The circadian clock governs a wide array of biological functions and is intimately...

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Bibliographic Details
Main Authors: Bala S C Koritala, Yin Yeng Lee, Laetitia S Gaspar, Shweta S Bhadri, Wen Su, Gang Wu, Lauren J Francey, Marc D Ruben, Ming C Gong, John B Hogenesch, David F Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002139

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https://doi.org/10.1371/journal.pbio.3002139

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