A Signature of Exaggerated Adipose Tissue Dysfunction in Type 2 Diabetes Is Linked to Low Plasma Adiponectin and Increased Transcriptional Activation of Proteasomal Degradation in Muscle

A Signature of Exaggerated Adipose Tissue Dysfunction in Type 2 Diabetes Is Linked to Low Plasma Adiponectin and Increased Transcriptional Activation of Proteasomal Degradation in Muscle

Insulin resistance in skeletal muscle in type 2 diabetes (T2D) is characterized by more pronounced metabolic and molecular defects than in obesity <i>per se</i>. There is increasing evidence that adipose tissue dysfunction contributes to obesity-induced insulin resistance in skeletal mus...

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Bibliographic Details
Main Authors: Rugivan Sabaratnam, Vibe Skov, Søren K. Paulsen, Stine Juhl, Rikke Kruse, Thea Hansen, Cecilie Halkier, Jonas M. Kristensen, Birgitte F. Vind, Bjørn Richelsen, Steen Knudsen, Jesper Dahlgaard, Henning Beck-Nielsen, Torben A. Kruse, Kurt Højlund
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
type 2 diabetes
obesity
adipose tissue dysfunction
skeletal muscle
transcriptomics
Online Access:https://www.mdpi.com/2073-4409/11/13/2005

Internet

https://www.mdpi.com/2073-4409/11/13/2005

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