Pharmacological Blockade of IKs Destabilizes Spiral-Wave Reentry Under β-Adrenergic Stimulation in Favor of Its Early Termination

Pharmacological Blockade of IKs Destabilizes Spiral-Wave Reentry Under β-Adrenergic Stimulation in Favor of Its Early Termination

We tested a hypothesis that an enhancement of IKs may play a pivotal role in ventricular proarrhythmia under high sympathetic activity. A 2-dimensional ventricular muscle layer was prepared in rabbit hearts, and action potential signals were analyzed by optical mapping. During constant stimulation,...

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Bibliographic Details
Main Authors: Sara Kato, Haruo Honjo, Yoshio Takemoto, Hiroki Takanari, Tomoyuki Suzuki, Yusuke Okuno, Tobias Opthof, Ichiro Sakuma, Shin Inada, Kazuo Nakazawa, Takashi Ashihara, Itsuo Kodama, Kaichiro Kamiya
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319305237

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http://www.sciencedirect.com/science/article/pii/S1347861319305237

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