Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion
Abstract Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available in vitro sandwich-cultured hepatocyte method is cumbersome because drugs accumulate in the closed bile canalicular lumen formed between hepatocytes and their amounts cannot...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05216-z |