Development of Chitosan–Tripolyphosphate Nanoparticles as Glycopeptide Antibiotic Reservoirs and Ex Vivo Evaluation for Their Potential to Enhance the Corneal Permeation in Ocular Drug Delivery

Development of Chitosan–Tripolyphosphate Nanoparticles as Glycopeptide Antibiotic Reservoirs and Ex Vivo Evaluation for Their Potential to Enhance the Corneal Permeation in Ocular Drug Delivery

Background: The present investigation aimed to prepare Vancomycin-loaded nanoparticles (VAN-NPs) using chitosan (CS) and tripolyphosphate (TPP) besides exploring the effects of changing CS/TPP ratio on the physicochemical properties, corneal permeation, and ocular delivery of the prepared NPs. Metho...

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Bibliographic Details
Main Authors: Farhad Safari, Shahla Mirzaeei, Ghobad Mohammadi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2022-07-01
Series:Pharmaceutical Sciences
Subjects:
antibiotic
chitosan
corneal permeation
nanoparticles
ocular drug delivery
vancomycin
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-28-449.pdf

Internet

https://ps.tbzmed.ac.ir/PDF/ps-28-449.pdf

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