Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells

Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells

TRPV4 (transient receptor potential vanilloid 4), a calcium permeable TRP ion channel, is known to play a key role in endocytosis. However, whether it contributes to exocytosis remains unclear. Here, we report that activation of TRPV4 induced massive exocytosis in both melanoma A375 cell and heterol...

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Bibliographic Details
Main Authors: Mei Li, Jiaojiao Zheng, Tian Wu, Yulin He, Jing Guo, Jiao Xu, Chuanzhou Gao, Shuxian Qu, Qianyi Zhang, Jiayu Zhao, Wei Cheng
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
TRPV4 ion channel
exocytosis
A375 cell
Ca<sup>2+</sup> signaling
ferroptosis
Online Access:https://www.mdpi.com/1422-0067/23/8/4146

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