Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness

Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness

IntroductionDespite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is a harbinger of poor long-term outcomes in sepsis survivors. Cur...

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Main Authors: Evan L. Barrios, Leandro Balzano-Nogueira, Valerie E. Polcz, Christine Rodhouse, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Shawn D. Larson, Ashish Sharma, Gilburt Upchurch, Shannon M. Wallet, Todd M. Brusko, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Rhonda Bacher, Guoshuai Cai, Michael P. Kladde, Clayton E. Mathews, Lyle L. Moldawer, Maigan A. Brusko, Philip A. Efron
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
lymphocytes
single-cell RNA sequencing
chronic critical illness
sepsis
human
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1478471/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1478471/full

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