Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes

Phosphoproteomic profiling of early rheumatoid arthritis synovium reveals active signalling pathways and differentiates inflammatory pathotypes

Abstract Background Kinases are intracellular signalling mediators and key to sustaining the inflammatory process in rheumatoid arthritis (RA). Oral inhibitors of Janus Kinase family (JAKs) are widely used in RA, while inhibitors of other kinase families e.g. phosphoinositide 3-kinase (PI3K) are und...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Cankut Çubuk, Rachel Lau, Pedro Cutillas, Vinothini Rajeeve, Christopher R. John, Anna E. A. Surace, Rebecca Hands, Liliane Fossati-Jimack, Myles J. Lewis, Costantino Pitzalis
Format: Artykuł
Język:English
Wydane: BMC 2024-06-01
Seria:Arthritis Research & Therapy
Dostęp online:https://doi.org/10.1186/s13075-024-03351-4

Internet

https://doi.org/10.1186/s13075-024-03351-4

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