A cutting-edge approach based on UHPLC-MS to simultaneously investigate oxysterols and cholesterol precursors in biological samples: Validation in Huntington's disease mouse model

A cutting-edge approach based on UHPLC-MS to simultaneously investigate oxysterols and cholesterol precursors in biological samples: Validation in Huntington's disease mouse model

Brain is most cholesterol-rich organ in the body. Since cholesterol does not cross the blood brain barrier, its metabolism is provided in situ by astrocytes and neurons, and it is crucial for maintaining sterol levels and neuronal integrity and function. Recent studies have shown that the levels of...

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Bibliographic Details
Main Authors: Alice Passoni, Monica Favagrossa, Marta Valenza, Giulia Birolini, Alessia Lanno, Caterina Mariotti, Elena Cattaneo, Mario Salmona, Laura Colombo, Renzo Bagnati
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:Talanta Open
Subjects:
Huntington's disease
Cholesterol metabolism
Liquid chromatography-mass spectrometry
Mouse plasma
Mouse brain
Online Access:http://www.sciencedirect.com/science/article/pii/S266683192300098X

Internet

http://www.sciencedirect.com/science/article/pii/S266683192300098X

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