Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking

Alzheimer’s disease (AD) is a chronic neurodegenerative disease which leads to the gradual loss of neuronal cells. Several hypotheses for AD exists (e.g., cholinergic, amyloid, tau hypotheses, etc.). As per the cholinergic hypothesis, the deficiency of choline is responsible for AD; therefore, the i...

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Библиографические подробности
Главные авторы: Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E.S. Wikberg, Chanin Nantasenamat
Формат: Статья
Язык:English
Опубликовано: PeerJ Inc. 2016-08-01
Серии:PeerJ
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Online-ссылка:https://peerj.com/articles/2322.pdf