Hypoxia Increases Nitric Oxide-Dependent Inhibition of Angiogenic Growth

Hypoxia Increases Nitric Oxide-Dependent Inhibition of Angiogenic Growth

Nitric oxide (NO) is a proangiogenic factor acting through the soluble guanylate cyclase (sGC) pathway. However, angiogenic growth increases energy demand, which may be hampered by NO inhibition of cytochrome c oxidase (CcO). Then, NO activity would be the balanced result of sGC activation (pro-angi...

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Bibliographic Details
Main Authors: Cristina Arce, Diana Vicente, Fermí Monto, Laura González, Cristina Nuñez, Víctor M. Victor, Francesc Jiménez-Altayó, Pilar D’Ocon
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Translational Medicine
Subjects:
nitric oxide
hypoxia
angiogenesis
mitochondrial O<sub>2</sub> consumption
Online Access:https://www.mdpi.com/2673-8937/1/3/22

Internet

https://www.mdpi.com/2673-8937/1/3/22

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