β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression

β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression

Glioblastoma multiforme (GBM) is the most invasive form of primary brain astrocytoma. Gene therapy using the herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) is a new strategy for GBM treatment. As the connexin 43 (Cx43) levels are downregulated in GBM cells, it seems that the upregula...

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Bibliographic Details
Main Authors: Saereh Hosseindoost, Seyed Mojtaba Mousavi, Ahmad Reza Dehpour, Seyed Amirhossein Javadi, Babak Arjmand, Ali Fallah, Mahmoudreza Hadjighassem
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
β2-adrenergic receptor
connexin 43
glioblastoma multiforme
olfactory ensheathing cells
gene therapy
bystander effect
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000766

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http://www.sciencedirect.com/science/article/pii/S2372770522000766

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