Mechanism and Improved Dissolution of Glycyrrhetinic Acid Solid Dispersion by Alkalizers

The purpose of this study was to increase the dissolution of glycyrrhetinic acid (GA) by preparing ternary solid dispersion (TSD) systems containing alkalizers, and to explore the modulating mechanism of alkalizers in solid dispersion systems. GA TSDs were prepared by hot melt extrusion (HME) with K...

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Bibliographic Details
Main Authors: Luning Dong, Yaping Mai, Qiang Liu, Wannian Zhang, Jianhong Yang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/12/1/82