KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer

Abstract Glycolysis is the most predominant metabolic reprogramming of pancreatic cancer (PC), the underlying mechanism of which in PC cells remains unclear. In this study, we found for the first time that KIF15 promotes the glycolytic capacity of PC cells and PC tumor growth. Moreover, the expressi...

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Bibliographic Details
Main Authors: Gang Quan, Jian Xu, Jie Wang, Xinyuan Liu, Jichuan Xu, Jianxin Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05679-2