Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

ABSTRACTIncreasing evidences suggest that HBsAg-production varies across HBV-genotypes. HBsAg C-terminus plays a crucial role for HBsAg-secretion. Here, we evaluate HBsAg-levels in different HBV-genotypes in HBeAg-negative chronic infection, the correlation of specific mutations in HBsAg C-terminus...

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Main Authors: Romina Salpini, Arianna Battisti, Lorenzo Piermatteo, Luca Carioti, Olympia E. Anastasiou, Upkar S. Gill, Domenico Di Carlo, Luna Colagrossi, Leonardo Duca, Ada Bertoli, Katia Yu La Rosa, Lavinia Fabeni, Alessandra Iuvara, Vincenzo Malagnino, Carlotta Cerva, Miriam Lichtner, Claudio M. Mastroianni, Giuseppe Maria De Sanctis, Maurizio Paoloni, Massimo Marignani, Caterina Pasquazzi, Nerio Iapadre, Giustino Parruti, Jacopo Vecchiet, Loredana Sarmati, Massimo Andreoni, Mario Angelico, Sandro Grelli, Patrick T. Kennedy, Jens Verheyen, Stefano Aquaro, Francesca Ceccherini-Silberstein, Carlo Federico Perno, Valentina Svicher
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
HBeAg-negative infection
HBsAg levels
HBsAg C-terminus
HBsAg mutations
HBV genotypes
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1757998

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https://www.tandfonline.com/doi/10.1080/22221751.2020.1757998

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