Characterization of genetic subclonal evolution in pancreatic cancer mouse models

Characterization of genetic subclonal evolution in pancreatic cancer mouse models

In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the utility of this model in mechanistic research o...

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Bibliographic Details
Main Authors: Noushin Niknafs, Yi Zhong, John Alec Moral, Lance Zhang, Melody Xiaoshan Shao, April Lo, Alvin Makohon-Moore, Christine A. Iacobuzio-Donahue, Rachel Karchin
Format: Article
Language:English
Published: Nature Portfolio 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13100-w

Internet

https://doi.org/10.1038/s41467-019-13100-w

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