Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome

Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome

Down syndrome (DS) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. Due to better treatment options for the physical co-morbidities of DS, the life expectancy of individuals with DS is beginning to approach that of the general population. Howe...

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Bibliographic Details
Main Authors: Wenche Stensen, Ulli Rothweiler, Richard Alan Engh, Melissa R. Stasko, Ilya Bederman, Alberto C. S. Costa, Anders Fugelli, John S. Mjøen Svendsen
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceuticals
Subjects:
protein kinase inhibitor
DYRK1A
down syndrome
neurodegeneration
learning and memory deficits
mouse models
Online Access:https://www.mdpi.com/1424-8247/14/11/1170

Internet

https://www.mdpi.com/1424-8247/14/11/1170

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