Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8+ T cell responses during chronic viral infection

Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8+ T cell responses during chronic viral infection

IntroductionActivation of T cell receptor (TCR) signaling is critical for clonal expansion of CD8+ T cells. However, the effects of augmenting TCR signaling during chronic antigen exposure is less understood. Here, we investigated the role of diacylglycerol (DAG)-mediated signaling downstream of the...

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Bibliographic Details
Main Authors: Shohei Harabuchi, Omar Khan, Hamid Bassiri, Taku Yoshida, Yohei Okada, Masaomi Takizawa, Osamu Ikeda, Akihiro Katada, Taku Kambayashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
TCR T cell receptor
diacylglycerol kinase (DGK)
ERK (extracellular signal-regulated kinase)
chronic viral infection
T cell exhaustion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032113/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032113/full

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