MHC binding affects the dynamics of different T-cell receptors in different ways.

T cells use their T-cell receptors (TCRs) to scan other cells for antigenic peptides presented by MHC molecules (pMHC). If a TCR encounters a pMHC, it can trigger a signalling pathway that could lead to the activation of the T cell and the initiation of an immune response. It is currently not clear...

Полное описание

Библиографические подробности
Главные авторы: Bernhard Knapp, P Anton van der Merwe, Omer Dushek, Charlotte M Deane
Формат: Статья
Язык:English
Опубликовано: Public Library of Science (PLoS) 2019-09-01
Серии:PLoS Computational Biology
Online-ссылка:https://doi.org/10.1371/journal.pcbi.1007338