Cerebral Microvascular Injury Induced by Lag3‐Dependent α‐Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α‐Synucleinopathies

Cerebral Microvascular Injury Induced by Lag3‐Dependent α‐Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α‐Synucleinopathies

Abstract The pathological accumulation of α‐synuclein (α‐Syn) and the transmission of misfolded α‐Syn underlie α‐synucleinopathies. Increased plasma α‐Syn levels are associated with cognitive impairment in Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies, but it is st...

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Bibliographic Details
Main Authors: Qingxi Zhang, Qingrui Duan, Yuyuan Gao, Peikun He, Rui Huang, Haifeng Huang, Yanyi Li, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
α‐Syn preformed fibril(s) (PFFs)
α‐synucleinopathies
cerebral microvascular injury
cognitive impairment
lymphocyte‐activation gene 3 (Lag3)
Online Access:https://doi.org/10.1002/advs.202301903

Internet

https://doi.org/10.1002/advs.202301903

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