Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges
Cardiomyocyte calcium-handling is the key mediator of cardiac excitation-contraction coupling. In the healthy heart, calcium controls both electrical impulse propagation and myofilament cross-bridge cycling, providing synchronous and adequate contraction of cardiac muscles. However, calcium-handling...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/7/1090 |
| _version_ | 1797440026735280128 |
|---|---|
| author | Henry Sutanto Jordi Heijman |
| author_facet | Henry Sutanto Jordi Heijman |
| author_sort | Henry Sutanto |
| collection | DOAJ |
| description | Cardiomyocyte calcium-handling is the key mediator of cardiac excitation-contraction coupling. In the healthy heart, calcium controls both electrical impulse propagation and myofilament cross-bridge cycling, providing synchronous and adequate contraction of cardiac muscles. However, calcium-handling abnormalities are increasingly implicated as a cause of cardiac arrhythmias. Due to the complex, dynamic and localized interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Therefore, multiscale computational modeling is increasingly being used together with laboratory experiments to unravel the exact mechanisms of calcium-mediated arrhythmogenesis. This article describes various examples of how integrative computational modeling makes it possible to unravel the arrhythmogenic consequences of alterations to cardiac calcium handling at subcellular, cellular and tissue levels, and discusses the future challenges on the integration and interpretation of such computational data. |
| first_indexed | 2024-03-09T12:02:09Z |
| format | Article |
| id | doaj.art-e08de0a23db343c392725b06b8562a95 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T12:02:09Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e08de0a23db343c392725b06b8562a952023-11-30T23:03:21ZengMDPI AGCells2073-44092022-03-01117109010.3390/cells11071090Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future ChallengesHenry Sutanto0Jordi Heijman1Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The NetherlandsDepartment of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The NetherlandsCardiomyocyte calcium-handling is the key mediator of cardiac excitation-contraction coupling. In the healthy heart, calcium controls both electrical impulse propagation and myofilament cross-bridge cycling, providing synchronous and adequate contraction of cardiac muscles. However, calcium-handling abnormalities are increasingly implicated as a cause of cardiac arrhythmias. Due to the complex, dynamic and localized interactions between calcium and other molecules within a cardiomyocyte, it remains experimentally challenging to study the exact contributions of calcium-handling abnormalities to arrhythmogenesis. Therefore, multiscale computational modeling is increasingly being used together with laboratory experiments to unravel the exact mechanisms of calcium-mediated arrhythmogenesis. This article describes various examples of how integrative computational modeling makes it possible to unravel the arrhythmogenic consequences of alterations to cardiac calcium handling at subcellular, cellular and tissue levels, and discusses the future challenges on the integration and interpretation of such computational data.https://www.mdpi.com/2073-4409/11/7/1090computational modelingcardiomyocytecalcium handlingcardiac arrhythmiaelectrophysiologyintegrative experiment |
| spellingShingle | Henry Sutanto Jordi Heijman Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges Cells computational modeling cardiomyocyte calcium handling cardiac arrhythmia electrophysiology integrative experiment |
| title | Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges |
| title_full | Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges |
| title_fullStr | Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges |
| title_full_unstemmed | Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges |
| title_short | Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac Arrhythmias: Current Status and Future Challenges |
| title_sort | integrative computational modeling of cardiomyocyte calcium handling and cardiac arrhythmias current status and future challenges |
| topic | computational modeling cardiomyocyte calcium handling cardiac arrhythmia electrophysiology integrative experiment |
| url | https://www.mdpi.com/2073-4409/11/7/1090 |
| work_keys_str_mv | AT henrysutanto integrativecomputationalmodelingofcardiomyocytecalciumhandlingandcardiacarrhythmiascurrentstatusandfuturechallenges AT jordiheijman integrativecomputationalmodelingofcardiomyocytecalciumhandlingandcardiacarrhythmiascurrentstatusandfuturechallenges |