Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders

Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders

Copy number variations (CNVs) of the human 16p11.2 locus are associated with several developmental/neurocognitive syndromes. Particularly, deletion and duplication of this genetic interval are found in patients with autism spectrum disorders, intellectual disability and other psychiatric traits. The...

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Bibliographic Details
Main Authors: Sandra Martin Lorenzo, Maria del Mar Muniz Moreno, Helin Atas, Marion Pellen, Valérie Nalesso, Wolfgang Raffelsberger, Geraldine Prevost, Loic Lindner, Marie-Christine Birling, Séverine Menoret, Laurent Tesson, Luc Negroni, Jean-Paul Concordet, Ignacio Anegon, Yann Herault
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Neuroscience
Subjects:
copy number variation
neurodevelopment
intellectual disability
autism spectrum disorders
rat model
social behavior
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1148683/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1148683/full

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