Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses

Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses

ABSTRACT Human noroviruses (HuNoV) are a leading cause of viral gastroenteritis worldwide and a significant cause of morbidity and mortality in all age groups. The recent finding that HuNoV can be propagated in B cells and mucosa-derived intestinal epithelial organoids (IEOs) has transformed our abi...

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Bibliographic Details
Main Authors: Myra Hosmillo, Yasmin Chaudhry, Komal Nayak, Frederic Sorgeloos, Bon-Kyoung Koo, Alessandra Merenda, Reidun Lillestol, Lydia Drumright, Matthias Zilbauer, Ian Goodfellow
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
intestine
organoid
interferons
mucosal pathogens
noroviruses
Online Access:https://journals.asm.org/doi/10.1128/mBio.00215-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00215-20

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