Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by Antidepressants

Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by Antidepressants

Commonly prescribed antidepressants may be associated with protection against severe COVID-19. The mechanism of their action in this context, however, remains unknown. Here, I investigated the effect of an antidepressant drug fluvoxamine on membrane trafficking of the SARS-CoV-2 spike protein and it...

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Bibliographic Details
Main Author: Oleg O. Glebov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Pharmacology
Subjects:
SARS-CoV-2
endocytosis
antidepressants
drug repurposing
COVID-19
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.787261/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.787261/full

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