<i>SDHA</i> Germline Mutations in SDH-Deficient GISTs: A Current Update
Loss of function of the succinate dehydrogenase complex characterizes 20–40% of all <i>KIT/PDGFRA</i>-negative GIST. Approximately half of SDH-deficient GIST patients lack <i>SDHx</i> mutations and are caused by a hypermethylation of the <i>SDHC</i> promoter, whic...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/14/3/646 |